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 Post subject: Zubsolv
PostPosted: Sat Dec 24, 2016 10:41 pm 
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I just wanted to write a brief paragraph or two on my experience with suboxone and also on my more recent switch to zubsolv and why it works better for me. First off I have been on bupe for about a year and a half this time around. (I don't feel like going into previous drug history) Just know that bupe has helped me. (and more than likely saved my life) But about 3 months ago I started noticing side effects such as stomach pains and urinary problems, as well as minor bowel issues. I am on 6mg I also did not look forward to dosing anymore. I absolutely cannot stand the taste of subs. And when you live a busy life, it can feel like hours waiting for your strip to dissolve. So i finally had enough of them and decided to switch to something else. I switched to zubsolv 5.7. I know there are alot of complaints that the lower dose formulation does not work as well, but for me I actually feel alot better on zub. I think it has something to do with the lower dose who knows. If anyone has a similar experience I would like for them to tell me about it. Let me know how and what works for you and which one you prefer and why. Thanks.


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 Post subject: Re: Zubsolv
PostPosted: Mon Dec 26, 2016 12:02 am 
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I started on suboxone then tried zubsolv. It was fine for the first couple of days, then I went into withdrawal, like I was not dosing at all. Then depression and terrible nightmares set in. Went back to suboxone and all its well again.

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 Post subject: Re: Zubsolv
PostPosted: Wed Dec 28, 2016 1:50 am 
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I need to tell you that you are not actually on a lower dose of buprenorphine, you are on a high dose. Zubsolv 5.7mg is the equivalent of 8 mg of suboxone. Zubsolv is supposed to have a higher bioavailability, meaning that more of the buprenorphine is absorbed from zubsolv than from suboxone.

I couldn't tell from your post whether you were aware that your dose is equivalent to 8mg of sub, so I wanted to make sure that you know. I take Zubsolv myself and the taste is so much better, I agree!

Amy

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 Post subject: Re: Zubsolv
PostPosted: Sat Dec 31, 2016 1:56 am 
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Yes- Zubsolv 5.7 mg = Suboxone 8 mg = Bunavail 4.3 mg. They all yield 2 mg of buprenorphine into the circulation. But Suboxone results in 6 mg of swallowed buprenorphine, and Bunavail only results on 2 mg swallowed. That swallowed buprenorphine is converted to norbuprenorphine, which is an opioid agonist that doesn't cross into the brain, but does impact the gut.

So you may feel different on Zubsolv from having less norbuprenorphine around. Maybe not-- that isn't really clear yet. But I do have several patients on Zubsolv who really like that medication over the other options.


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 Post subject: Re: Zubsolv
PostPosted: Sat Dec 31, 2016 11:02 pm 
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For me, the taste and the quicker absorption is a no brainer for me. One thing that I dont understand is why some peope insist the lesser formulation gives them withdrawals. I think they just prefer one over the other and it has nothing to do with actual withdrawals. Who knows.


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