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PostPosted: Fri Sep 26, 2014 2:47 am 
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Can you tell me what is considered to be a therapeutic blood level of Buprenorphine? On the internet I have read that it raange between 1 and 8 ng/ml, while a level of 20 ng/ml in the blood indicates abuse.


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PostPosted: Sat Oct 04, 2014 9:07 pm 
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You got me on that one. We normally refer to it by milligrams, ie; mg's. What does ng stand for? The ml I got, milliliters.

To answer it in milligrams, I'd say somewhere around 8 mg's seems to cut the cravings and is at or above the ceiling. The ceiling effect I believe is 4 mg's.

But everybody has a different addiction level and system. Meaning, a doctor shouldn't give a heroin addict the same dose as a 8 per day Vicodin addict. That's why patients fill out all that paperwork before being induced. I remember writing it all down, omitting nothing. It was the first time I was honest with anyone about my addiction and how much I was taking.

Did that help any?

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PostPosted: Sat Oct 04, 2014 9:46 pm 
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I think the op is referring to nanograms per ml in the blood, as in when the levels of bupe are lab tested. Am I correct op? I don't have an answer on that one either I'm afraid. I did a bit of Google searching, but came up empty. Hopefully Dr. Junig will be able to answer this one if he sees it. He's generally pretty busy, but he does stop by the forum from time to time to check things out.


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PostPosted: Sun Oct 05, 2014 2:16 am 
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Hi, not sure if this can be of any help to you, but, just as an example over the past four months here are my own lab results taking the 2mg Suboxone tablets, and my doctor said, "Your levels are perfect!" every time. To be honest, the first two labs I was on a higher dose, (4mg a day), and the last couple I was cut down to 3mgs and then again to 2 and a half mgs but my doctor provided me with some extra 2mg tablets to take half of PRN for withdrawal and to be honest, I felt the most therapeutic dosage, for me at least, was at 3 to 3 and a half mgs.

UDS of 6/04/14 showed BUP = 138: Nor-BUP = 307. No other substances found.

USD of 7/07/14 showed BUP = 104: Nor-BUP = 183. No other substances found.

UDS of 08/19/14 showed BUP = 11: Nor-BUP = 80. No other substances found.

UDS of 09/02/14 showed BUP = 27: Nor-BUP = 200. No other substances found

Not sure if it helps at all, but, my doctor says all these are perfectly therapeutic levels.

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Fond Du Lac Psychiatry
Dr. Jeffrey Junig, M.D., Ph.D.

  • Board Certified Psychiatrist
  • Asst Clinical Professor, Medical College of Wisconsin

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