It is currently Tue Aug 22, 2017 8:51 pm



All times are UTC - 5 hours [ DST ]


Our Sponsors





Post new topic Reply to topic  [ 3 posts ] 
Author Message
 Post subject: Sinemet for RLS?
PostPosted: Mon Jan 20, 2014 9:02 pm 
Offline
Average Poster
Average Poster

Joined: Fri Jan 17, 2014 5:47 pm
Posts: 5
After searching the internet for things to help with RLS which is the main issue that has kept me from stopping opiates and am worried about when stopping Suboxone I saw that Sinemet (Carbidopa-Levodopa) is a possibility. Does anyone have any knowledge on this?


Top
 Profile  
 
 Post subject: Re: Sinemet for RLS?
PostPosted: Mon Jan 20, 2014 11:57 pm 
Offline
Site Admin
Site Admin
User avatar

Joined: Sun Feb 24, 2008 11:03 pm
Posts: 1544
There are different causes for RLS, and I don't think it is known if there are similar mechanisms behind the primary disorder of RLS, vs. the RLS of opioid withdrawal. Sinemet increases CNS dopamine-- which is reduced in Parkinson's disease, the main indication for Sinemet. There are other drugs that treat RLS through dopamine pathways, such as 'Requip', a dopamine agonist.

But during withdrawal, central sympathetic activity is increased, which is one of the reasons clonidine reduces withdrawal. Adding Sinemet would INCREASE CNS sympathetic tone-- which might make withdrawal symptoms worse.

The question is interesting though; I've wondered, in the past, if Requip or other dopamine agents would reduce RLS, or instead would worsen it... I do not know of any studies that look at dopamine drugs and the 'kicking' associated with opioid withdrawal. I can't recommend it... but if someone prescribes it to you and you try it, be sure to report your 'findings' here!


Top
 Profile  
 
 Post subject: Re: Sinemet for RLS?
PostPosted: Sun Jan 26, 2014 12:54 am 
Offline
Average Poster
Average Poster

Joined: Sat Jan 25, 2014 11:39 pm
Posts: 7
In my experience, Requip does absolutely nothing for opiate related RLS.

RLS is the worst part of withdrawal for me too. I hope clonidine and lope will help with that.


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 3 posts ] 

All times are UTC - 5 hours [ DST ]


Who is online

Users browsing this forum: No registered users and 1 guest


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Search for:
Jump to:  
Our Sponsors
Suboxone Forum latest topics RSS feed Subscribe to the entire forum
 

 

 
Fond Du Lac Psychiatry
Dr. Jeffrey Junig, M.D., Ph.D.

  • Board Certified Psychiatrist
  • Asst Clinical Professor, Medical College of Wisconsin

Powered by phpBB® Forum Software © phpBB Group