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PostPosted: Fri Nov 06, 2015 3:03 am 
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First of all, it's not nice to disparage a bunch of people that you don't know for any reason.

Secondly, you seem to be ignorant to a couple of facts yourself. It very much matters how much buprenorphine you are absorbing in your mouth before you swallow your saliva. When saliva builds up in your mouth that means that there is less bupe content in each milliliter of saliva in your mouth. Therefore less bupe is coming in contact with the mucous membranes of your mouth and less being absorbed.

That is why Dr. Junig, who runs this forum has blog posts on tips for increasing your absorption.

Once the buprenorphine in the saliva is swallowed there is no more chance to absorb more. The concern about some of the new formulations of the buprenorphine/naloxone combination is that some forms, like Zubsolv are thought to be more easily absorbed. Therefore the 8 mg of buprenorphine in a suboxone film is decreased to 5.4 mg of buprenorphine per Zubsolv pill. So 8 mg of bupe is not 8 mg of bupe. 8 mg of bupe is 5.4 mg of bupe in this formulations, but they are both supposed to have the same effect because the latter absorbs better. Yet, some people, including myself, have found this not to be the case. In my case I was on 2 mg and when I was switched by my insurance to Zubsolv I found that their 1.4 pill did not fill my receptors like the 2 mg film. So my doctor raised my dose to 1.5 Zubsolv pills.

An ibuprofen 800mg pill is the same as an 800mg Motrin pill, not only because it's the same mgs, but because it is absorbed in the stomach, not in the mucous membranes of the mouth.

I hope that enlightens you more about what our members were talking about in this thread. You are welcome to our forum unless you decide that you want to disparage people here instead of being helpful. In that case, you are welcome to leave.

Amy

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PostPosted: Fri Nov 06, 2015 11:54 am 
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What's amazing to me is that anyone would think that taking a medication that goes under ur tongue getting mixed with saliva would think that 100% is getting absorbed. I don't need to say anything else because Amy took care of that.

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Fond Du Lac Psychiatry
Dr. Jeffrey Junig, M.D., Ph.D.

  • Board Certified Psychiatrist
  • Asst Clinical Professor, Medical College of Wisconsin

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