It is currently Sun Dec 17, 2017 4:23 am



All times are UTC - 5 hours [ DST ]


Our Sponsors





Post new topic Reply to topic  [ 3 posts ] 
Author Message
PostPosted: Tue Oct 25, 2011 12:57 am 
Offline
Long Time Member
Long Time Member
User avatar

Joined: Thu Jul 15, 2010 5:08 am
Posts: 1497
Quote:
Drug Users - Young Drug Users' Brain Damage Similar to Alzheimer's
Damaged Observed as Early as Age 17
By Buddy T, About.com Guide
Updated October 30, 2010


Young drug abusers are up to three times more likely to suffer brain damage than those who don't use drugs, according to research published online by Neuropathology and Applied Neurobiology.
Scientists at the University of Edinburgh studied the brains of 34 deceased intravaneous drug abusers of heroin and methadone and compared them to the brains of 16 young people who were not drug users. Their examination revealed brain damage in the drug abusers normally seen in much older people.

The damaged nerve cells were in the areas of the brain involved in learning, memory and emotional well being, and were similar to damage found in the early stages of Alzheimer's disease.

"Our study shows evidence of an increased risk of brain damage associated with heroin and methadone use, which may be highest in the young, when individuals are most likely to acquire the habit" said co-author Jeanne Bell Professor of Neuropathology. "We found that the brains of these young drug abusers showed significantly higher levels of two key proteins associated with brain damage."

"In a previous study we found out that drug abuse causes low grade inflammation in the brain. Taken together, the two studies suggest that intravenous opiate abuse may be linked to premature ageing of the brain," Bell said.

Heroin and Methadone Cause Damage

The average age in these two groups in the study was only 26 years and included some drug abusers as young as 17.
"Tau protein, which in its soluble form is essential for communication and transport within brain cells, had become insoluble in some cells, causing nerve cell damage and death in selected areas of the brain," the authors reported. "Other nerve cells showed an accumulation of the amyloid precursor protein, which suggests that protein transport had been disrupted and the nerve cell functions affected."

Severe Nerve Cell Damage

"This study shows that drug abuse can lead to a build up of proteins which cause severe nerve cell damage and death in essential parts of the brain. This is very worrying as there are strong indications that drug use in the UK, in particular opiates like heroin and methadone, has continued to rise in recent years" says Professor Bell.
"The drug abusers we looked at in the study sadly died at a young age, but there are many others who don't realise the long-term effects that these drugs may be causing."

Source: S. N. Ramage, I. C. Anthony, F. W. Carnie, A. Busuttil, R. Robertson, J. E. Bell, "Hyperphosphorylated tau and amyloid precursor protein deposition is increased in the brains of young drug abusers," Neuropathology and Applied Neurobiology, June 2005.


Unfortunately I can't read anywhere any discussion of whether non-IV opiate users, or users of other opiates than heroin & methadone, will also suffer these issues. I don't see any reason why not.


Top
 Profile  
 
 Post subject:
PostPosted: Tue Oct 25, 2011 7:27 pm 
Offline
Long Time Member
Long Time Member
User avatar

Joined: Thu Jul 21, 2011 10:43 am
Posts: 893
Location: AZ
This is quite interesting and not in a good way. However I do wonder if the iv'ing could have something to do with it. IV drug users tend to get infections and other diseases so perhaps that could be affecting the brain. I don't see a reason that it would matter which opiate you use, as far as your brains concerned there all the same. It would be nice if they did a study on non IV users to see if it makes a difference.


Top
 Profile  
 
 Post subject:
PostPosted: Tue Oct 25, 2011 10:19 pm 
Offline
Long Time Member
Long Time Member
User avatar

Joined: Fri Mar 12, 2010 12:43 am
Posts: 1017
Location: Buffalo New York
I am with Breezy at the end of the day heroine, morphine, codeine or whatever it may be it is all the same to the brain some are just stronger than others. As of IV use vs. non IV use, I think that who the study is being done on is huge with this. As for some white kid from the suburbs who has clean needles from the exchange, clean water and so on vs. a person living on the streets sharing needles, using old needles, using dirty water, and all the other nasty stuff being a street junkie lintels would play a huge role on how it effects the human body.

_________________
Yes these drugs saved our life's. But does that mean we have to give the rest of our life to these drugs?


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 3 posts ] 

All times are UTC - 5 hours [ DST ]


Who is online

Users browsing this forum: No registered users and 0 guests


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Search for:
Jump to:  
Our Sponsors
Suboxone Forum latest topics RSS feed Subscribe to the entire forum
 

 

 
Fond Du Lac Psychiatry
Dr. Jeffrey Junig, M.D., Ph.D.

  • Board Certified Psychiatrist
  • Asst Clinical Professor, Medical College of Wisconsin

Powered by phpBB® Forum Software © phpBB Group