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PostPosted: Wed Aug 14, 2013 10:43 am 
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So, Deepak Chopra is the kind of guy, you either love him or you hate him. Well he's advertising this product Endorphinate on his site. It's supposed to increase endorphin production. Now at first this could seem like a great supplement to have while coming off subs/tapering/living life after subs, since the body is adjusting to not having this blast of endorphins every time it uses. Or, it could be bad to put a bunch of extra crap in your body that doesn't really do anything. So I found a list of stuff in the pills, and was hoping someone here could say Yay or Nay on this.

Link to the 3 Endorphinate Products where you can buy them (one for anxiety, one for sleep, one for pain relief): http://store.chopra.com/deepak_chopra_endorphinate


Link to .pdf about this huge scientific explanation on how the product works, plus a list of stuff in it that starts on page 11:

http://ponderapharma.com/wp-content/uploads/2011/10/Endorphinate%C2%AE-Science-Principles1.pdf


And here is the copied and pasted list of the stuff in it:

Ingredients for Endorphinate® products are chosen from each of the following three functional groups, depending on the targeted indications.

OPIOID RECEPTOR SWITCHERS:

N-Acetyl-Cysteine (NAC) – an amino acid, which switches opioid receptor signaling from excitatory to inhibitory by producing sulfates which function as a neuraminidase inhibitor. NAC is also a powerful antioxidant with antiviral and detoxification capacities. Alone, NAC can help to reduce cravings, obsessions, and compulsions; when combined with endorphin enhancers, such as guarana and ginkgo biloba, the synergistic effect can help to produces pain and distress relief, reduction of anxiety and cravings, as well as enhanced mood and well being.

L-Theanine – an amino acid that is found naturally in green tea and functions as an opioid receptor switcher. L-theanine also increases GABA and dopamine levels, which can help to reduce anxiety and improve mood. Nature synergistically combines caffeine with L-theanine in green tea, in order to produce a unique blend of energy combined with calm and well being.

Magnesium Glycyl Glutamine – a stabilized form of the amino acid, glutamine, combines the natural opioid receptor switching power of the endorphin breakdown dipeptide product, glycyl-L-glutamine with the calming influence of magnesium. Glycyl-L-glutamine has been shown to help reduce the maladaptive noxious effects of both endogenous opioids (endorphins) and exogenous opioids (e.g, morphine).

Magnesium Sulfate – a natural compound that combines the potent opioid receptor switching effects of sulfate, a natural GM1 ganglioside blocker, with the calming influence of magnesium. Magnesium sulfate, or Epsom salt, has been shown to help relieve pain as well as reduce noxious side-effects of exogenous opioids.


ENDORPHIN ENHANCERS:

Guarana – a natural seed that contains caffeine, theophylline, and other components, which are endorphin enhancing agents. These are cAMP PDE inhibitors that prevent the metabolic breakdown of cAMP, enhancing the concentration of endorphins. Guarana releases endorphin enhancing agents more gradually than other sources and does not create “spikes” and other side effects, making it a natural source for prolonged release of endorphins in the Endorphinate® formulation.

Ginkgo Biloba – an herbal endorphin-enhancing agent that is also a cAMP PDE inhibitor. This inhibitor specifically targets cAMP within inflammatory and immune cells enhancing the release of endorphins within these cells. Ginkgo biloba is also a powerful antioxidant that helps to enhance energy, circulation, memory and concentration.

Glutamic Acid – an excitatory amino acid that directly enhances cAMP, which increases endorphin levels. When combined with opioid receptor switchers, glutamic acid has been shown to help produce analgesia.


SYNERGISTIC ENHANCERS:

Pyridoxal 5 Phosphate, Folic Acid, and Vitamin B-12. – vitamins that are critical cofactors in the production of endorphin, serotonin, GABA, dopamine and related neurotransmitters.

Magnesium Taurinate – naturally combines magnesium and an important inhibitory amino acid, taurine, which synergistically amplify their effects on calming anxiety, agitation, irritability, cravings, and hyperactivity. The addition of magnesium taurinate to the Endorphinate®™ formulation potentiates pain and distress relief, and enhances a sense of calm and well being as well as focus and motivation.

L-Theanine – a natural amino acid that enhances GABA and dopamine, thereby potentiating the calming and relaxing effects of the core Endorphinate® ingredients. L-theanine also functions as an Opioid Receptor Switcher (see above).

Lemon Balm – a natural herb that can help reduce anxiety and insomnia while also enhancing memory and attention. Lemon balm synergizes the calming effects of L-theanine and other Endorphinate® ingredients.

Ashwagandha – a natural herb can help reduce anxiety, pain, and insomnia and to help the mind and body respond effectively to stress. Ashwagandha has anti-inflammatory effects as well as benefits for the gastrointestinal and immunological systems. Ashwagandha is also known for its ability to improve energy, motivation, attention, and sexual functioning.

Ginger Extract – a natural herb that can help to reduce pain and inflammation. Ginger is also known for its health-promoting benefits for gastrointestinal functioning.

Green Tea Extract – an herb that naturally contains L-theanine, an opioid receptor switcher, and caffeine, an endorphin enhancer, thereby providing core components to produce endorphinergic balance and relief from emotional and physical distress. Green tea also contains health-promoting polyphenols, which can help boost the immunological system with powerful antioxidant benefits.

White Willow Bark – a plant extract that contains salicin and other natural components, which have pain and inflammation relieving benefits. White willow bark is a natural product that has been shown to synergistically enhance the pain and stress relieving effects of the core Endorphinate® formulation. People who are sensitive to aspirin should not use white willow bark.

5-Hydroxytryptophan (5-HTP) – a naturally-occurring amino acid, which is directly involved in the biosynthesis of serotonin and melatonin. By enhancing levels of serotonin and melatonin, 5-HTP naturally helps to produce a sense of calm, well being, and positive mood, which is synergistically potentiated when combined with Endorphin Enhancers and Opioid Receptor Switchers.

Acetyl-L-Carnitine (ALC) – a powerful antioxidant with neuroprotective functions that can help prevent the development of age-related conditions, including cognitive and other neurological impairments as well cardiac, neuromuscular, and sexual conditions. These benefits synergize with the core Endorphinate® formulations to potentiate the relief of aches and pains and other distress conditions.

Alpha Lipoic Acid (ALA) – an omega-3 fatty acid and a powerful antioxidant and anti-inflammatory that that can help prevent the development of age-related conditions, including arthritis, diabetes, neuropathy, and cardiovascular conditions.


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PostPosted: Thu Aug 15, 2013 2:31 pm 
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I don't think anyone here can say one way or another if it's a good product or not. Maybe one of our doctors who pop in here can say something about it.

It put me to sleep trying to read it all~~~~~ just joking.

r

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PostPosted: Thu Aug 15, 2013 7:36 pm 
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I have read numerous times that amino acids help with wd sypmtoms. Have you ever googled the 'thomas recipe' for opiate wd? One of the supplements on that list is an amino acid called L-thyrosine. The bottle of l-thyrosine i bought from gnc says 'essential for healthy nervous system function'

Ive spent loads of time trying to learn about the healing process from opioid dependance, and things that may help, but its really complicated! If its not to expensive maybe it wouldnt hurt to try or you could just invest in a wide spectrum amino acid supplement from gnc along with a good multi-vitamin. I think supplements can help to a degree, but the best healer is time.


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Fond Du Lac Psychiatry
Dr. Jeffrey Junig, M.D., Ph.D.

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