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PostPosted: Thu Aug 04, 2016 7:20 pm 
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Hi all,

I am a male, late 20's with low testosterone that is caused by my long-term Suboxone use. My urologist believes that Clomid will help with my low t and won't cause any fertility issues. I am wondering if Clomid's mechanism of action will help opioid-related low t? My doctor isn't positive if it will, but he says it's worth a shot. Has anyone had any success with Clomid and Suboxone-related low t?


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PostPosted: Thu Aug 04, 2016 7:48 pm 
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Have not heard of it. According to that fund of all knowledge, Wikepedia, Clomifene works by blocking estrogen receptors in the hypothalamus, an area of the brain involved in basic regulatory functions of the body (thirst, hunger, sex drive, sleep cycles, etc). I guess my first thought is whether men have estrogen receptors in the hypothalamus-- and if they do, whether those receptors play a role in the reduction in testosterone production caused by opioids.

Your doc doesn't sound real sure of him/herself on the issue, although maybe you're paraphrasing... and I know nothing about the issue. I'll try to do some reading this weekend....


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PostPosted: Fri Aug 05, 2016 2:55 pm 
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Thanks for looking into this, Doc. From my less than basic understanding of testosterone in the male body, there is a percentage of testosterone and estrogen in the male body that the body knows to keep balanced. Somehow Clomid tricks the brain into producing more testosterone by turning the estrogen receptor off? The comment about my doctor not having a good understanding of the drug is probably accurate, but unfortunately the only doctor that I have been to that even knows about opioid-related low t is my pain management Doctor. My GP, endocrinologist and urologist have no idea that opiod low t is even a thing :/


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PostPosted: Sat Aug 06, 2016 6:05 pm 
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Hey, I appreciate the info! This is not in my area of expertise, but I'll have to learn more about it. There is definitely evidence for the effect, and the benefit appears to be significant-- this study showed testosterone levels more than doubled, whereas the cream never seems to boost it more than 20-30%: http://www.ncbi.nlm.nih.gov/pubmed/16422830

Again, I appreciate the info. The approach also seems to be a better approach than just giving testosterone, as the testosterone is metabolized to estrogen, which causes 'man-boobs' and other problems (a.k.a. gynecomastia).


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