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 Post subject: Ceiling Effect
PostPosted: Fri Apr 07, 2017 7:32 pm 
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Hey :D Can anyone explain to me what the ceiling effect of sub is plz? I am new to suboxone/subutex so I've been researching, which lead me here. I keep coming across the term "ceiling effect" but do not fully understand what this is. Thanks so much for your responses!


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 Post subject: Re: Ceiling Effect
PostPosted: Fri Apr 07, 2017 7:54 pm 
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Welcome Jessica,
The best advice I can give you would be to go to Dr Junigs Talkzone and watch his vidio on the Ceiling Effect. There are a few of them.
Or you may go to the Seach box at the top of the page and type in Ceiling effect. You ll get great answers there too.
Glad you ve made it to our forum and your new life on Buprenorphine /Suboxone. So much to learn and this is the place to do it.
The Ceiling is believed to be around 4/8 mgs depending on the person.


Razor


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 Post subject: Re: Ceiling Effect
PostPosted: Fri Apr 07, 2017 9:05 pm 
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in very simple terms your sub dose should be higher than your opiate level was. (at least that is my take on it. someone please correct me if that is wrong) there are calculations and conversions and such out there.

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 Post subject: Re: Ceiling Effect
PostPosted: Fri Apr 07, 2017 9:28 pm 
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Thanks. I tried searching it here but nothing came up, still learning to navigate the site & get where I want! Lol


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 Post subject: Re: Ceiling Effect
PostPosted: Fri Apr 07, 2017 9:30 pm 
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The ceiling effect is one of the properties of buprenorphine, which is a partial agonist, that makes it more safe than full agonist. The ceiling effect means that buprenorphine will only depress respiration to a certain extent, which is too little to cause overdose and death in an opiate tolerant person.

Dr. Junig really does explain it best, so here are links to a couple of helpful threads that answer the question:

http://suboxonetalkzone.com/the-bupreno ... ng-effect/

http://suboxonetalkzone.com/ceilings/

If you have more questions feel free to ask!

Amy

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 Post subject: Re: Ceiling Effect
PostPosted: Fri Apr 07, 2017 9:53 pm 
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Thanks Amy!
For anyone who didn't click or read. Dr. said to read this one paragraph repeatedly until you understand!

"If the blood level of buprenorphine is ABOVE that ceiling, the opioid receptors are maximally, 100% stimulated. If the person takes more buprenorphine, and the blood level increases, the opioid receptors don’t feel the increase, as they cannot be stimulated more than 100%. But more importantly: when the person takes less, and the blood level of buprenorphine goes DOWN, the receptors also sense nothing– as long as the level stays above the ‘ceiling’ level."

I also found this very useful. I had just commented about it on the skipping a day post.
"A person can eliminate that second dose fairly easily, providing that the morning dose is high enough, i.e. usually 8-16 mg. To eliminate the second dose, the person should distract him/herself as soon as the thought about taking the second dose comes to mind. Immediately, do anything else—the dishes, call a friend, wrestle with the dogs… and the thought will pass. If the person does the distraction method for a few days, the need to take the second dose will go away—a psychological process called ‘extinguishment.’"

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 Post subject: Re: Ceiling Effect
PostPosted: Fri Apr 07, 2017 11:13 pm 
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That's why I'm here! To guide people to the best info possible!

Thanks, Sis, for including those helpful paragraphs in your post!

Amy

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Fond Du Lac Psychiatry
Dr. Jeffrey Junig, M.D., Ph.D.

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