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PostPosted: Tue Mar 23, 2010 1:38 pm 
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This is a continuation of something from another thread. If you notice any errors, let me know please.

Okay. After many hours of deliberation I have come up with an equation that you can use to figure out the dose you will really be coming off of if you take your dose every certain amount of time. It takes about 2 weeks of taking the same dose at the same time to reach this maximum. The spreadsheet will soon follow this. Until then, you can just plug this equation into google.

Image

Where,
T = dosing interval (period)
D = dose
t1/2 = half-life of drug
ln2 = 0.693147 (approx.)
e = 2.71828

And both the half-life and dosing period need to be in the same unit (i.e. usually hours).

Or, if the half-life is 37 hours (the mean half-life for buprenorphine) it can be simplified to:

Image

In google, type it in as:

D/(1-e^(-T*.693/Half-life))

For regular (non-scientific) calculators:
Do the numerator and denominator separately:

First solve –T*.693
Then divide that number by the half-life
Then raise 2.71 to the (the number from directly above) power
Now do 1 minus that number from directly above
Now do D (dose) divided by the number from above.

I'll be back. I might not do more work today (it's nice outside) but I promise I will get all this done over the break.


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PostPosted: Tue Mar 23, 2010 3:08 pm 
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Joined: Fri Mar 19, 2010 9:57 pm
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For example, according to this, if you take an 4 8 mg Suboxones every day you will eventually accumulate 88 mg of buprenorphine. I have known some doctors to START PEOPLE OUT at 32 mg a day. Obviously, that is an UNBELIEVABLE amount of buprenorphine to have coursing through your veins. Of course, in reality there are more variables and it might be more or less but I think this at least a good "order of magnitude" estimation.


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Fond Du Lac Psychiatry
Dr. Jeffrey Junig, M.D., Ph.D.

  • Board Certified Psychiatrist
  • Asst Clinical Professor, Medical College of Wisconsin

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